2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W014504S1
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid-d7 98%
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid-d7 is the deuterium labeled 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid. 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
    2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid-d7
  • HY-W014787S1
    Decanedioic acid-d16 73351-71-0 98%
    Decanedioic acid-d16 is the deuterium labeled Decanedioic acid (HY-W014787). Decanedioic acid is a straight-chain dicarboxylic acid. Dodecanedioic acid overcomes metabolic inflexibility in type 2 diabetes. Decanedioic acid prevents and reverses metabolic-associated liver disease and obesity. Decanedioic acid is associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency.
    Decanedioic acid-d16
  • HY-W015240S1
    N-Acetyl-L-glutamic acid-d4 98%
    N-Acetyl-L-glutamic acid-d4 is the deuterium labeled N-Acetyl-L-glutamic acid. N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human.
    N-Acetyl-L-glutamic acid-d4
  • HY-W015273AR
    trans-3-Indoleacrylic acid (Standard) 29953-71-7
    trans-3-Indoleacrylic acid (Standard) is the analytical standard of trans-3-Indoleacrylic acid. This product is intended for research and analytical applications. Trans-3-Indoleacrylic acid is a tryptophan metabolite, which promotes tumor development through inhibition of RSL3 (HY-100218A) induced ferroptosis via AHR-ALDH1A3-FSP1-CoQ10 axis, and facilitates colorectal carcinogenesis[1]
    trans-3-Indoleacrylic acid (Standard)
  • HY-W015300S1
    Suberic acid-d12 169397-99-3 98.60%
    Suberic acid-d12 is the deuterium labeled Suberic acid. Suberic acid (Octanedioic acid) is found to be associated with carnitine-acylcarnitine translocase deficiency, malonyl-Coa decarboxylase deficiency.
    Suberic acid-d12
  • HY-W015410S2
    Disodium succinate-d4 203633-14-1 98%
    Disodium succinate-d4 is the deuterium labeled Disodium succinate. Disodium succinate is the disodium salt of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
    Disodium succinate-d4
  • HY-W015464S1
    N-Isovaleroylglycine-d2 1219795-09-1 98%
    N-Isovaleroylglycine-d2 is the deuterium labeled N-Isovaleroylglycine. N-Isovaleroylglycine is an acyl glycine and could be used as a biomarker for the predispositon for weight gain and obesity.
    N-Isovaleroylglycine-d2
  • HY-W015883S2
    Fumaric acid-13C2,d2 100858-52-4 98%
    Fumaric acid-13C2,d2 is the deuterium and 13C labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
    Fumaric acid-13C2,d2
  • HY-W015883S4
    Fumaric acid-d4 194160-45-7 98%
    Fumaric acid-d4 is the deuterium labeled Fumaric acid. Fumaric acid, associated with fumarase deficiency, is identified as an oncometabolite or an endogenous, cancer causing metabolite.
    Fumaric acid-d4
  • HY-W015913S3
    Sodium 2-oxopropanoate-13C 124052-04-6 98%
    Sodium 2-oxopropanoate-13C is the 13C labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.
    Sodium 2-oxopropanoate-13C
  • HY-W015913S4
    2-Oxopropanoate-13c2 sodium 89196-78-1 98%
    2-Oxopropanoate-13C5 (sodium) is the 13C labeled Sodium 2-oxopropanoate. Sodium 2-oxopropanoate (Sodium pyruvate), a three-carbon metabolite of Glucose, is a compound produced in the glycolytic pathway. Sodium 2-oxopropanoate is a free radical scavenger that can scavenge ROS.
    2-Oxopropanoate-13c2 sodium
  • HY-W016009S1
    2'-Deoxyadenosine-5'-monophosphate-15N5,d12 dilithium 98%
    2'-Deoxyadenosine-5'-monophosphate-15N5,d12 dilithium is deuterium and 15N labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-15N5,d12 dilithium
  • HY-W016009S2
    2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium 98%
    2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium is 15N labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-15N5 dilithium
  • HY-W016009S3
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium 98%
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium is 13C-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-13C10 dilithium
  • HY-W016009S4
    2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium 2483830-51-7 98%
    2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium is 13C and 15N-labeled 2'-Deoxyadenosine-5'-monophosphate (HY-W016009). 2′-Deoxyadenosine 5′-monophosphate, a nucleic acid AMP derivative, is a deoxyribonucleotide found in DNA. 2′-Deoxyadenosine 5′-monophosphate can be used to study adenosine-based interactions during DNA synthesis and DNA damage.
    2'-Deoxyadenosine-5'-monophosphate-13C10,15N5 dilithium
  • HY-W016562S3
    Hippuric acid-15N 93627-88-4 98%
    Hippuric acid-15N is the 15N-labeled Hippuric acid. Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
    Hippuric acid-15N
  • HY-W017018S1
    L-Ornithine-1,2-13C2 hydrochloride 224054-19-7 98%
    L-Ornithine-1,2-13C2 (hydrochloride) is the 13C-labeled L-Ornithine hydrochloride. L-Ornithine hydrochloride is a free amino acid that plays a central role in the urea cycle and is also important for the disposal of excess nitrogen.
    L-Ornithine-1,2-13C2 hydrochloride
  • HY-W017443S3
    L-Asparagine-15N2,d3 monohydrate 98%
    L-Asparagine-15N2,d3 monohydrate is the deuterium and 15N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-15N2,d3 monohydrate
  • HY-W017443S4
    L-Asparagine-1,2,3,4-13C4 monohydrate 768348-44-3 98%
    L-Asparagine-1,2,3,4-13C4 monohydrate is the 13C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.
    L-Asparagine-1,2,3,4-13C4 monohydrate
  • HY-W017522S5
    Adipic acid-d4-1 19031-55-1 98%
    Adipic acid-d4-1 (Hexanedioic acid-d4-1) is the deuterium labeled Adipic acid (HY-W017522). Adipic acid (Hexanedioic acid) is an orally active compound with anti-HSV-1 activity. Adipic acid has low toxicity and can be used as a food additive and a gelling agent. Adipic acid can also be used in the synthesis of lubricants, artificial resins, plastics, etc.
    Adipic acid-d4-1
Cat. No. Product Name / Synonyms Application Reactivity